Opportunity Information: Apply for PAR 23 024
The Catalyst Award for Early-Stage Investigators (ESIs) Pursuing Research on HIV Comorbidities, Coinfections, and Complications (DP1 - Clinical Trial Optional) is a National Institutes of Health (NIH) funding opportunity designed to back bold, high-risk and high-reward ideas from early-stage investigators. The intent is to help newer investigators launch unusually creative, pioneering research that could open up genuinely new directions in HIV/AIDS science, specifically around the added health burdens that occur alongside HIV, such as comorbidities (other chronic conditions), coinfections (additional infectious diseases occurring with HIV), and complications (downstream health effects and clinical challenges tied to HIV and its treatment). A core expectation is that proposed projects are not simply the next incremental step in an applicant's existing research program; instead, they should represent a distinct, novel scientific departure, with fresh concepts or approaches that are not already widely being pursued by the investigator or the broader field.
A key requirement is alignment with NIH HIV/AIDS research priorities as set by the NIH Office of AIDS Research (OAR). Applicants are expected to ensure their ideas fit within those overarching priorities, which are referenced as being described in NOT-OD-20-018. In practical terms, that means the work should be clearly connected to priority HIV research gaps and strategic directions identified by OAR, rather than being HIV-adjacent in a vague way. The FOA is labeled "Clinical Trial Optional," meaning studies may include clinical trials but do not have to; applicants can propose mechanistic, translational, clinical, implementation, or other study types as long as they fit the purpose of pioneering work on HIV-related comorbidities, coinfections, and complications and meet NIH and program-specific requirements.
This opportunity is issued as a discretionary grant under the NIH, with the funding opportunity number PAR 23 024. It falls under a broad health and social services activity category and is associated with multiple CFDA (Assistance Listing) numbers, including 93.233, 93.398, 93.837, 93.838, 93.839, 93.840, 93.847, and 93.865, reflecting NIH involvement across several institutes or program areas that touch HIV and its related conditions. The stated award ceiling is $350,000, which signals a relatively bounded budget compared with large center grants, but one that can still support a focused, innovative project intended to catalyze a new research trajectory. The original closing date listed for the opportunity is 2025-05-01.
Eligibility is broad and includes many types of U.S.-based organizations and government entities. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations that are not federally recognized tribal governments; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other qualifying entities. The FOA also explicitly highlights additional eligible applicant categories such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), along with faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. This emphasis signals an openness to a wide range of institutional settings, including those serving historically underrepresented or underserved communities, which can be particularly relevant for HIV research given disparities in HIV burden and outcomes.
At the same time, the FOA draws clear boundaries around non-U.S. participation. Non-domestic (non-U.S.) entities, described as foreign organizations or foreign institutions, are not eligible to apply as the applicant organization. Non-domestic components of U.S. organizations are also not eligible to apply. However, "foreign components" as defined by the NIH Grants Policy Statement are allowed, which generally means a U.S. applicant may include certain scientifically justified activities performed outside the U.S. under NIH rules, provided the application meets NIH requirements for foreign components and maintains a U.S.-based applicant institution.
Overall, this FOA is best understood as a targeted NIH mechanism to help early-stage investigators take serious, innovative swings at difficult and underexplored HIV-related health challenges that go beyond HIV infection alone. The emphasis is on originality, the likelihood of opening new avenues for HIV/AIDS research, and clear alignment with NIH OAR strategic priorities, with flexible study design options including but not limited to clinical trials.Apply for PAR 23 024
- The National Institutes of Health in the education, food and nutrition, health, income security and social services sector is offering a public funding opportunity titled "Catalyst Award for Early-Stage Investigators (ESIs) Pursuing Research on HIV Comorbidities, Coinfections, and Complications (DP1- Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.398, 93.837, 93.838, 93.839, 93.840, 93.847, 93.865.
- This funding opportunity was created on 2022-08-24.
- Applicants must submit their applications by 2025-05-01. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $350,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Enhancing the Use of the All of Us Research Programs Data (R21 Clinical Trial Not Allowed) Apply for RFA PM 23 001 Funding Number: RFA PM 23 001 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Small Grants to Enhance the Use of the All of Us Research Programs Data (R03 Clinical Trial Not Allowed) Apply for RFA PM 23 002 Funding Number: RFA PM 23 002 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH Science Education Partnership Award (SEPA) (R25 - Clinical Trial Not Allowed) Apply for PAR 23 137 Funding Number: PAR 23 137 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $250,000 |
| Emergency Awards: HEAL Initiative- New Innovator Award (DP2 Clinical Trial Not Allowed) Apply for RFA TR 23 011 Funding Number: RFA TR 23 011 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $1,500,000 |
| HEAL Initiative: Interdisciplinary Team Science to Uncover the Mechanisms of Pain Relief by Medical Devices (RM1 Clinical Trial Optional) Apply for RFA NS 23 028 Funding Number: RFA NS 23 028 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $1,500,000 |
| HEAL Initiative: HEAL KIDS (Knowledge, Innovation and Discovery Studies) Pain: Acute Pain Clinical Trials Program (U01 Clinical Trial Required) Apply for RFA HD 24 011 Funding Number: RFA HD 24 011 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Non-addictive Analgesic Therapeutics Development [Small Molecules and Biologics] to Treat Pain (UG3/UH3 Clinical Trial Optional) Apply for RFA NS 24 019 Funding Number: RFA NS 24 019 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed) Apply for PAR 24 075 Funding Number: PAR 24 075 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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| HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed) Apply for RFA NS 25 012 Funding Number: RFA NS 25 012 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $350,000 |
| Advancing HIV service delivery through pharmacies and pharmacists (R01 Clinical Trial Optional) Apply for RFA MH 25 185 Funding Number: RFA MH 25 185 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| NIH HEAL Initiative PainCare Clinician Training Program (PCTP): Mentored Clinical Scientist Development Awards (K08 - Clinical Trials Required) Apply for PAR 24 217 Funding Number: PAR 24 217 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| Time-Sensitive Obesity Policy and Program Evaluation (R01) Apply for PAR 15 346 Funding Number: PAR 15 346 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
| HEAL Initiative: Studies to Enable Analgesic Discovery (R61/R33 - Clinical Trial Not Allowed) Apply for RFA NS 25 023 Funding Number: RFA NS 25 023 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: $350,000 |
| Time-Sensitive Evaluation of Policies Affecting Health Behaviors and Chronic Disease Risk (R01-Clinical Trial Not Allowed) Apply for PAR 25 312 Funding Number: PAR 25 312 Agency: National Institutes of Health Category: Education, Food and Nutrition, Health, Income Security and Social Services Funding Amount: Case Dependent |
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