Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R01) | PAR 23 040

Opportunity Information: Apply for PAR 23 040

This NIH grant opportunity (PAR 23-040) is an R01 research project grant run through the Office of Research Infrastructure Programs (ORIP). Its core purpose is to strengthen animal-based biomedical research by funding the development and real-world implementation of broadly useful technologies, tools, and resources that help validate animal models and improve the rigor, reproducibility, and translatability of animal studies. In practice, ORIP is looking for projects that make animal research more reliable from lab to lab and more predictive of human biology, so the resulting methods or resources can raise the overall quality and usefulness of animal-model research across the NIH portfolio.

Projects submitted to this FOA are expected to be hypothesis-driven and supported by strong preliminary data, which signals that the program is not intended for very early, exploratory concepts without evidence of feasibility. The funded work should produce something broadly applicable: for example, a new technology platform, a standardized validation framework, a shared resource, a rigorous benchmarking dataset, or other widely adoptable tools that directly address common sources of variability or bias in animal experiments. A key requirement is that applicants clearly explain and demonstrate how the proposed approach will measurably improve rigor and reproducibility in animal studies, not just advance a specific disease area or a single lab's model system.

To align with ORIP's NIH-wide mission, the proposed studies, models, resources, or technologies must have scope beyond a narrow niche. Specifically, they need to either serve the research interests of multiple NIH Institutes and Centers, span multiple organ systems, or apply to diseases and biological processes that affect multiple organ systems. That emphasis is meant to ensure the deliverables can be used across many research areas rather than being tailored to one specialty. The broader the impact across animal-model research communities, the better the fit.

Eligibility is broad and includes many types of domestic applicants: state, county, and local governments; special districts; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Tribal governments; other Tribal organizations; public housing authorities; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); small businesses; and other eligible entities. The FOA also explicitly notes categories such as HBCUs, Hispanic-serving institutions, Tribal colleges and universities, AANAPISI institutions, Alaska Native and Native Hawaiian Serving Institutions, faith-based or community-based organizations, regional organizations, U.S. territories or possessions, and eligible federal agencies.

At the same time, there are important restrictions related to foreign participation. Non-domestic (non-U.S.) entities and foreign institutions are not eligible to apply as the applicant organization. Non-domestic components of U.S. organizations are also not eligible to apply. However, foreign components, as defined in the NIH Grants Policy Statement, are allowed, meaning a U.S.-based applicant may include certain foreign collaborations or work components if they meet NIH policy requirements and are justified within the project.

Administratively, the opportunity is categorized as discretionary funding and uses the NIH R01 grant mechanism under CFDA 93.351. The funding opportunity was created on 2022-10-28, and the listed original closing date is 2025-07-05. The award ceiling and expected number of awards are not specified in the provided listing, which typically means applicants should consult the full FOA text and NIH budget guidance for any limits, expectations, and application instructions. Overall, the program is best suited for teams that can show convincing preliminary evidence and a clear plan to deliver widely adoptable methods or resources that materially improve how animal studies are designed, validated, compared, and reproduced across different labs and research domains.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Development of Resources and Technologies for Enhancing Rigor, Reproducibility, and Translatability of Animal Models in Biomedical Research (R01)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.351.
• This funding opportunity was created on 2022-10-28.
• Applicants must submit their applications by 2025-07-05. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for PAR 23 040

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