Opportunity Information: Apply for PAR 22 167
The NIH is offering a limited competition funding opportunity called the Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award (CCIA), using a UG3/UH3 cooperative agreement mechanism (clinical trial optional). The core idea is to speed up and strengthen the translational research pipeline by funding teams that can work across organizational boundaries to solve problems that slow translation in many disease areas. Instead of focusing on a single disease or a single institution, this program is centered on collaborative, cross-cutting solutions that can be reused, scaled, and adopted broadly, with the ultimate goal of getting more interventions to more people faster.
The CCIA is designed to support projects that develop, demonstrate, and disseminate innovative approaches that transform translational science. In practice, that means applicants are expected to identify common inefficiencies that show up across conditions (for example, bottlenecks in study start-up, challenges in participant recruitment and retention, inconsistent data standards, delays in regulatory workflows, limited interoperability across systems, or barriers to equitable access) and propose practical solutions that can be tested and then shared for wider use. A major emphasis is on synergy: the opportunity is built for collaborative science among CTSA Program hubs, relevant NIH Institutes, Centers, and Offices (ICOs), and potentially external stakeholders. The goal is not just a local improvement at one site, but an innovation that can move the field forward and be disseminated so others can adopt it.
This is a cooperative agreement, which generally signals that NIH expects substantial involvement with awardees during the project. Compared with a standard research grant, cooperative agreements typically come with more active scientific and programmatic partnership from NIH staff, often including milestone-driven management and coordinated efforts across participating groups. The UG3/UH3 structure commonly supports a phased approach: an initial stage (UG3) focused on planning, feasibility, and early proof-of-concept work, followed by a transition to an implementation stage (UH3) if predefined milestones are met. The "clinical trial optional" label indicates that proposed work may include a clinical trial if appropriate, but it is not mandatory; applicants can propose non-trial translational infrastructure, methods, or process innovations as long as they align with the program goals.
Eligibility is limited and primarily geared toward U.S.-based public and state-controlled institutions of higher education, consistent with the "limited competition" framing and the CTSA hub-centered collaboration model. Foreign institutions are not eligible to apply, and non-U.S. components of U.S. organizations are also not eligible to apply. At the same time, foreign components (as NIH defines them in the NIH Grants Policy Statement) are allowed, meaning certain internationally based elements of a project can be included when justified and compliant, even though the applicant organization itself must be eligible and U.S.-based. This structure reinforces the expectation that projects are anchored in the CTSA ecosystem while still allowing carefully scoped global elements when they add value.
Key administrative details from the listing include the funding opportunity title and number (PAR-22-167) and the sponsoring agency (National Institutes of Health). It is categorized as a discretionary opportunity and uses a cooperative agreement funding instrument. The activity category is listed under Health, Income Security and Social Services, and associated CFDA numbers include 93.121, 93.307, 93.313, 93.350, 93.846, 93.859, and 93.865, reflecting the NIH programs that may be involved. The original closing date shown is 2024-10-17. The award ceiling and expected number of awards are not specified in the provided source data, so applicants would need to consult the full FOA text or NIH notices for budget limits, project period expectations, and any cohort size targets.
Overall, this opportunity is best understood as NIH asking CTSA-linked teams to tackle shared, system-level problems in translation with solutions that are not only innovative but also demonstrably workable and designed for broad dissemination. Competitive projects are likely to emphasize strong multi-site or multi-stakeholder collaboration, clear milestones for the phased UG3/UH3 approach, measurable acceleration outcomes (such as reduced cycle times, improved quality or reproducibility, increased reach or equity, or better interoperability), and a realistic plan for adoption beyond the originating hub or partnership.Apply for PAR 22 167
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Limited Competition: Clinical and Translational Science Award (CTSA) Program: Collaborative and Innovative Acceleration Award (UG3/UH3 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.121, 93.307, 93.313, 93.350, 93.846, 93.859, 93.865.
- This funding opportunity was created on 2022-05-09.
- Applicants must submit their applications by 2024-10-17. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: Public and State controlled institutions of higher education.
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