Opportunity Information: Apply for W81XWH 22 SCIRP CTA
The Department of Defense Spinal Cord Injury Research Program (SCIRP) Clinical Trial Award (CTA) is a funding opportunity designed to move spinal cord injury (SCI) research into human testing quickly, with a clear emphasis on real-world impact. The core purpose is to support clinical trials that could meaningfully improve how SCI is treated or managed, whether that means better functional outcomes, improved health and quality of life, fewer complications, or more effective long-term care. A strong application is expected to explain not only what will be tested, but also why the results could matter in both the near term and the longer term for people living with SCI and for their care-partners.
This award is centered on running clinical trials, and it is broad in the kinds of interventions it will consider as long as they align with one or more of the FY22 SCIRP Focus Areas. Supported trials can evaluate new or promising products, pharmacologic agents such as drugs or biologics, medical devices, clinical guidance or care practices, and emerging approaches or technologies. In other words, the program is open to a wide range of clinical-stage ideas, but it is not meant for purely exploratory basic science; it is meant for studies where people will actually be enrolled and an intervention will be tested in a structured way. The intent is rapid implementation, so proposals should read like they are ready to execute, with a clear plan for recruitment, endpoints, and operational feasibility.
The SCIRP CTA allows flexibility in trial scale and maturity. Projects can range from small proof-of-concept efforts, including pilot studies, first-in-human work, or phase 0 trials, when the goal is to demonstrate feasibility, establish early safety signals, or generate data needed to design a larger pivotal study. At the other end of the spectrum, the program also supports larger trials designed to determine efficacy in relevant SCI populations. While randomized clinical trials are common, the announcement explicitly allows alternative trial designs as long as the design fits the scientific and clinical objective. That means applicants can propose nontraditional approaches when randomization is impractical or when another design better answers the question, but they still need to justify the approach and show it will produce interpretable evidence.
Administratively, the opportunity is run by the Department of Defense, Department of the Army, through the U.S. Army Medical Research Acquisition Activity (USAMRAA). The funding opportunity number is W81XWH 22 SCIRP CTA, and it falls under CFDA 12.420 (research and development). The funding instrument type listed includes both grants and cooperative agreements, which typically signals that some awards may involve more substantial government involvement or coordination during the project period, depending on how the award is structured. Eligibility is described as unrestricted, meaning a wide range of applicant organizations can apply, subject to any clarifications that might appear in the full eligibility text. The posting date is March 28, 2022, with an original closing date of September 2, 2022. The agency expected to make about four awards under this announcement, and the listing shows an award ceiling of 0, which usually indicates that a specific maximum was not provided in the summary field and would need to be confirmed in the full announcement or program guidelines.
Overall, this grant mechanism is best understood as a push to translate SCI innovations into clinical evidence, with priority on interventions that could plausibly change clinical practice or care pathways for people living with SCI. Competitive proposals would typically make a strong case for significance and impact, align clearly to the program focus areas, present a credible and well-justified trial design, and demonstrate readiness to carry out the study efficiently while producing outcomes that matter to individuals with SCI and their care networks.Apply for W81XWH 22 SCIRP CTA
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DOD, Spinal Cord Injury Research Program, Clinical Trial Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Mar 28, 2022.
- Applicants must submit their applications by Sep 02, 2022. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 4 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DoD Spinal Cord Injury Research Program (SCIRP) Clinical Trial Award (CTA)
What is the SCIRP Clinical Trial Award (CTA)?
The Department of Defense Spinal Cord Injury Research Program (SCIRP) Clinical Trial Award (CTA) is a funding opportunity focused on moving spinal cord injury (SCI) research into human testing quickly. It supports clinical trials intended to generate real-world evidence that could improve treatment or management of SCI.
What is the main goal of this award?
The central goal is to fund clinical trials that could meaningfully improve outcomes for people living with SCI, such as better function, improved health and quality of life, fewer complications, or more effective long-term care. Applications are expected to explain both what will be tested and why the results could matter in the near term and the longer term for individuals with SCI and their care-partners.
What types of projects are a good fit for this opportunity?
Projects that are ready to run as clinical trials, where people will be enrolled and an intervention will be tested in a structured way, are the intended fit. The program emphasizes rapid implementation and operational feasibility.
Does this award support basic science or exploratory research?
This mechanism is not aimed at purely exploratory basic science. It is designed for clinical-stage studies involving human participants and a defined trial structure.
What kinds of interventions can be tested in supported clinical trials?
The CTA is broad and can support trials evaluating new or promising products, pharmacologic agents (including drugs or biologics), medical devices, clinical guidance or care practices, and emerging approaches or technologies, as long as they align with one or more of the FY22 SCIRP Focus Areas.
Do proposed clinical trials need to align with specific program priorities?
Yes. Supported trials must align with one or more of the FY22 SCIRP Focus Areas.
How mature can a trial be to qualify under this award?
The CTA allows flexibility in trial scale and maturity. It can support small proof-of-concept efforts (including pilot studies, first-in-human work, or phase 0 trials) as well as larger trials intended to determine efficacy in relevant SCI populations.
Are pilot studies or first-in-human studies allowed?
Yes. The announcement indicates that proof-of-concept projects such as pilot studies, first-in-human work, and phase 0 trials can be supported when the objective is to demonstrate feasibility, establish early safety signals, or generate data needed to design a larger pivotal study.
Does the program only fund large efficacy trials?
No. While larger efficacy-focused trials are supported, the program also supports earlier-stage clinical trials aimed at feasibility and early safety signals.
Are randomized clinical trials required?
No. Randomized clinical trials are common, but the announcement allows alternative trial designs if the design fits the scientific and clinical objective.
If a non-randomized or nontraditional design is proposed, what is expected?
The design must be justified and shown to produce interpretable evidence. The application should clearly explain why randomization is impractical or why another approach better answers the trial question.
What does the program mean by "rapid implementation"?
It means proposals should appear ready to execute, with a clear plan for recruitment, endpoints, and operational feasibility, rather than being preliminary concepts that still require major groundwork before enrolling participants.
What outcomes is the program trying to improve for people with SCI?
The program highlights outcomes such as improved functional outcomes, better health and quality of life, fewer complications, and more effective long-term care and management of SCI.
Who runs this funding opportunity?
It is administered by the Department of Defense, Department of the Army, through the U.S. Army Medical Research Acquisition Activity (USAMRAA).
What is the funding opportunity number for this announcement?
The funding opportunity number is W81XWH 22 SCIRP CTA.
What is the CFDA number associated with this opportunity?
The listing notes CFDA 12.420 (research and development).
What type of funding instrument is used (grant or cooperative agreement)?
The listing includes both grants and cooperative agreements. This can indicate that some awards may involve more substantial government involvement or coordination during the project period, depending on the specific award structure.
Who is eligible to apply?
Eligibility is described as unrestricted, meaning a wide range of applicant organizations may apply, subject to any clarifications contained in the full eligibility language for the opportunity.
When was this opportunity posted?
The posting date shown is March 28, 2022.
What was the original closing date?
The original closing date shown is September 2, 2022.
How many awards were expected to be made?
The agency expected to make about four awards under this announcement.
What is the maximum award amount (award ceiling)?
The listing shows an award ceiling of 0, which generally indicates that a specific maximum was not provided in the summary field and would need to be confirmed in the full announcement or program guidelines.
What makes an application competitive based on the summary provided?
Competitive proposals typically (1) make a strong case for significance and real-world impact, (2) align clearly to the FY22 SCIRP Focus Areas, (3) present a credible and well-justified trial design (including justification for any nontraditional designs), and (4) demonstrate readiness to execute efficiently with feasible recruitment plans, clear endpoints, and operational practicality.
What kinds of impacts should applicants describe?
Applicants are expected to discuss why the trial results could matter in the near term and the longer term, including potential to change clinical practice or care pathways, and benefits for people living with SCI and their care-partners.
Is the program focused on translating innovations into clinical evidence?
Yes. The mechanism is positioned as a push to translate SCI innovations into clinical evidence, prioritizing interventions that could plausibly influence real-world care.
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| DOD, Spinal Cord Injury Research Program, Investigator-Initiated Research Award Apply for W81XWH 22 SCIRP IIRA Funding Number: W81XWH 22 SCIRP IIRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD, Spinal Cord Injury Research Program, Translational Research Award Apply for W81XWH 22 SCIRP TRA Funding Number: W81XWH 22 SCIRP TRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD, Autism Research Program, Idea Development Award Apply for W81XWH 22 ARP IDA Funding Number: W81XWH 22 ARP IDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD, Autism Research Program, Career Development Award Apply for W81XWH 22 ARP CDA Funding Number: W81XWH 22 ARP CDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD, Autism Research Program, Clinical Trial Award Apply for W81XWH 22 ARP CTA Funding Number: W81XWH 22 ARP CTA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD Ovarian Cancer Clinical Trial Award Apply for W81XWH 22 OCRP CTA Funding Number: W81XWH 22 OCRP CTA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Campus Cyberinfrastructure Apply for 22 582 Funding Number: 22 582 Agency: National Science Foundation Category: Science and Technology and other Research and Development Funding Amount: $1,000,000 |
| Gen-4 Engineering Research Centers Apply for 22 580 Funding Number: 22 580 Agency: National Science Foundation Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Cybersecurity Innovation for Cyberinfrastructure Apply for 22 581 Funding Number: 22 581 Agency: National Science Foundation Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD, Tuberous Sclerosis Complex Research Program, Clinical Translational Research Award Apply for W81XWH 22 TSCRP CTRA Funding Number: W81XWH 22 TSCRP CTRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD, Tuberous Sclerosis Complex Research Program, Idea Development Award Apply for W81XWH 22 TSCRP IDA Funding Number: W81XWH 22 TSCRP IDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DOD, Tuberous Sclerosis Complex Research Program, Exploration – Hypothesis Development Award Apply for W81XWH 22 TSCRP EHDA Funding Number: W81XWH 22 TSCRP EHDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Peer Reviewed, Impact Award Apply for W81XWH 22 PRCRP IPA Funding Number: W81XWH 22 PRCRP IPA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Peer Reviewed, Convergent Science Cancer Consortium Development Award Apply for W81XWH 22 PRCRP CSCCDA Funding Number: W81XWH 22 PRCRP CSCCDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Peer Reviewed, Behavioral Health Science Award Apply for W81XWH 22 PRCRP BHSA Funding Number: W81XWH 22 PRCRP BHSA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Peer Reviewed, Translational Team Science Award Apply for W81XWH 22 PRCRP TTSA Funding Number: W81XWH 22 PRCRP TTSA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Peer Reviewed, Career Development Award Apply for W81XWH 22 PRCRP CDA Funding Number: W81XWH 22 PRCRP CDA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| DoD Peer Reviewed, Idea Award Apply for W81XWH 22 PRCRP IA Funding Number: W81XWH 22 PRCRP IA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
| Global Innovation through Science and Technology: Global, ASEAN, and Pacific Islands Apply for SFOP0008814 Funding Number: SFOP0008814 Agency: Department of State, Office of Acquisitions Management Category: Science and Technology and other Research and Development Funding Amount: $1,360,649 |
| U.S.-ASEAN Science, Technology and Innovation Cooperation (STIC) Program Apply for SFOP0008796 Funding Number: SFOP0008796 Agency: Department of State, Bureau of East Asian and Pacific Affairs Category: Science and Technology and other Research and Development Funding Amount: $3,456,250 |
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