Opportunity Information: Apply for RFA AR 25 002
The Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRC) funding opportunity (RFA-AR-25-002) is an NIH discretionary grant competition that supports the creation or continuation of specialized research centers focused on muscular dystrophy. It uses the P50 center grant mechanism, which is designed for multidisciplinary, team-based programs that bring multiple projects and shared resources together under a single, coordinated center structure. The notice is labeled "Clinical Trial Optional," meaning applicants may propose clinical trials if they are scientifically justified and appropriate for the center, but proposing a clinical trial is not required to be responsive.
The goal of this opportunity is to advance muscular dystrophy research through dedicated centers that can integrate complementary lines of investigation, coordinate expertise across disciplines, and build shared infrastructure that accelerates progress. While the source text provided does not list specific scientific topics or required core components, the MDSRC model typically emphasizes collaboration, resource sharing, and a unified strategy that is stronger than a collection of independent projects. In practice, that usually means a center-level plan for leadership and governance, a set of interrelated research activities, and centralized cores or services that enable the work and support the broader muscular dystrophy research community.
Eligibility is broad and includes many types of domestic organizations. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofits with or without 501(c)(3) status (other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other entities. The announcement also highlights additional eligible applicant categories such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible agencies of the federal government, regional organizations, Indian/Native American Tribal Governments (other than federally recognized), and U.S. territories or possessions.
There are important foreign eligibility limits. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the applicant organization, and non-domestic components of U.S. organizations are also not eligible to apply. However, "foreign components" are allowed as defined in the NIH Grants Policy Statement, which generally means a U.S. applicant can include a defined portion of the work being performed outside the U.S. when it is scientifically necessary and appropriately justified, subject to NIH policy and review.
Administrative details in the posting indicate the sponsoring agency is the National Institutes of Health, the funding instrument is a grant, and the activity category is Health, Income Security and Social Services. The opportunity is associated with multiple CFDA numbers (93.233, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.865), reflecting NIH program areas that may be involved in funding or oversight. The original closing date listed is 2024-07-03, and the creation date of the posting is 2024-05-09. The listed award ceiling is $1,000,000, which indicates the maximum amount expected per award under the terms summarized in the source data (actual budgets and allowable costs typically depend on NIH policy, the specific FOA instructions, and justification in the application). The number of expected awards is not specified in the provided text.
Overall, this opportunity is aimed at U.S.-based institutions and organizations capable of running a center-level muscular dystrophy research program, with the option (but not the requirement) to include clinical trials. It emphasizes a coordinated specialized research center approach rather than a single-project grant, and it allows international collaboration only through allowable foreign components under NIH rules, not through foreign organizations applying directly.Apply for RFA AR 25 002
- The National Institutes of Health in the health, income security and social services sector is offering a public funding opportunity titled "Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRC) (P50 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.233, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, 93.865.
- This funding opportunity was created on 2024-05-09.
- Applicants must submit their applications by 2024-07-03. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,000,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Frequently Asked Questions (FAQs)
What is the Senator Paul D. Wellstone Muscular Dystrophy Specialized Research Centers (MDSRC) funding opportunity?
This opportunity (RFA-AR-25-002) is an NIH discretionary grant competition that supports the creation or continuation of specialized research centers focused on muscular dystrophy. It is designed to fund a coordinated center program rather than a single, stand-alone research project.
Which agency is sponsoring this grant opportunity?
The sponsoring agency is the National Institutes of Health (NIH).
What type of funding instrument is used?
The funding instrument is a grant.
What grant mechanism does this opportunity use?
This opportunity uses the P50 center grant mechanism, which is intended for multidisciplinary, team-based programs that integrate multiple projects and shared resources under a single center structure.
What is the main goal of the MDSRC program?
The goal is to advance muscular dystrophy research through dedicated centers that integrate complementary lines of investigation, coordinate expertise across disciplines, and build shared infrastructure that accelerates research progress.
Is this opportunity intended for a single research project or a coordinated center?
It is intended for a coordinated specialized research center. The center model typically emphasizes collaboration, resource sharing, and a unified strategy that is stronger than a collection of independent projects.
Are clinical trials required?
No. The notice is labeled "Clinical Trial Optional." Applicants may propose clinical trials if they are scientifically justified and appropriate for the center, but proposing a clinical trial is not required to be responsive.
Can applicants include clinical trials in their proposed center activities?
Yes. Clinical trials may be proposed if they are scientifically justified and appropriate for the overall center plan, consistent with the "Clinical Trial Optional" designation.
What kinds of organizations are eligible to apply?
Eligibility is broad and includes many types of domestic (U.S.-based) organizations, including various government entities, higher education institutions, nonprofits, and for-profit organizations (including small businesses).
Which government entities are eligible applicants?
Eligible government applicants include state governments; county governments; city or township governments; special district governments; independent school districts; and eligible agencies of the federal government. U.S. territories or possessions and regional organizations are also listed among eligible categories.
Are colleges and universities eligible to apply?
Yes. Eligible applicants include public and state-controlled institutions of higher education and private institutions of higher education.
Are minority-serving institutions specifically mentioned as eligible?
Yes. The announcement highlights additional eligible applicant categories including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), and Tribally Controlled Colleges and Universities (TCCUs).
Are tribal governments and tribal organizations eligible?
Yes. Eligible applicants include federally recognized Native American tribal governments as well as Native American tribal organizations other than federally recognized tribal governments. The announcement also highlights Indian/Native American Tribal Governments (other than federally recognized).
Are nonprofits eligible to apply?
Yes. Nonprofits with or without 501(c)(3) status (other than institutions of higher education) are eligible applicants.
Are for-profit organizations eligible to apply?
Yes. For-profit organizations other than small businesses are eligible, and small businesses are also eligible.
Are faith-based or community-based organizations eligible?
Yes. Faith-based or community-based organizations are highlighted among additional eligible applicant categories.
Can a foreign (non-U.S.) organization apply as the applicant institution?
No. Non-domestic (non-U.S.) entities (foreign organizations) are not eligible to apply as the applicant organization for this opportunity.
Can a non-domestic component of a U.S. organization apply?
No. Non-domestic components of U.S. organizations are also not eligible to apply as the applicant.
Are foreign components allowed in an application?
Yes. "Foreign components" are allowed as defined in the NIH Grants Policy Statement. In general, a U.S. applicant may include a defined portion of the work being performed outside the U.S. when it is scientifically necessary and appropriately justified, subject to NIH policy and review.
What does the center model typically emphasize?
Based on the description provided, the MDSRC model typically emphasizes collaboration, resource sharing, and a unified center strategy. In practice, that often includes a center-level plan for leadership and governance, interrelated research activities, and centralized cores or services that enable the research and support the broader muscular dystrophy research community.
Does the provided information list required scientific topics or required core components?
No. The source text provided does not list specific scientific topics or required core components.
What is the activity category listed for this opportunity?
The activity category is Health, Income Security and Social Services.
Which CFDA numbers are associated with this opportunity?
The opportunity is associated with multiple CFDA numbers: 93.233, 93.837, 93.838, 93.839, 93.840, 93.846, 93.853, and 93.865.
What is the closing date listed in the posting?
The original closing date listed is 2024-07-03.
What is the creation date of the posting?
The creation date of the posting is 2024-05-09.
What is the maximum (ceiling) award amount shown?
The listed award ceiling is $1,000,000, indicating the maximum amount expected per award under the summarized source data. Actual budgets and allowable costs typically depend on NIH policy, the specific FOA instructions, and the justification provided in the application.
How many awards does NIH expect to make?
The number of expected awards is not specified in the provided information.
Is this opportunity limited to U.S.-based applicants?
Yes. The opportunity is aimed at U.S.-based institutions and organizations. International collaboration is allowed only through allowable foreign components under NIH rules, not by foreign organizations applying directly.
What does "NIH discretionary grant competition" mean in this context?
The opportunity is described as an NIH discretionary grant competition, meaning it is a competed NIH funding opportunity where applicants submit proposals for review and potential award under the terms of the specific funding announcement.
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