Opportunity Information: Apply for RFA HL 20 009

BLOODSAFE is a National Institutes of Health (NIH), Department of Health and Human Services funding opportunity that focuses on a practical public health and clinical problem in Sub-Saharan Africa: many patients who urgently need transfusions cannot reliably access safe blood, particularly in low or lower-middle income countries. The program is designed to fund research projects that strengthen the full pathway from donor recruitment through collection, testing, storage, and last-mile delivery so that transfusion-ready blood is available when and where it is needed. A central motivation is the high burden of severe anemia and hemorrhage in the region, including life-threatening cases among children with malaria or sickle cell disease and among pregnant women experiencing obstetric hemorrhage. The overall goal is not only to generate evidence, but to develop strategies that are feasible within local health systems and sustainable beyond the life of the grant.

The opportunity (Funding Opportunity Number RFA HL 20 009) uses a cooperative agreement mechanism and is labeled UG3/UH3 with clinical trials optional. In practice, this typically signals a phased approach in which an initial phase supports planning and early milestones, followed by a second phase focused on implementation, testing, and evaluation, with NIH staff having substantial programmatic involvement compared with a standard research grant. The emphasis is on strategies that can be demonstrated in real-world settings, including hard-to-reach or remote areas where the logistics of transporting blood, maintaining cold chain requirements, and coordinating with clinical facilities can be especially challenging.

BLOODSAFE invites research aimed at three broad, connected outcomes. First, it supports work to increase the number of safe blood donors, which can include improving recruitment, retention, donor selection, and community engagement approaches that fit local contexts. Second, it encourages projects to improve the quality and safety of the blood supply, which may involve better screening and testing processes, quality management systems, safer collection and processing workflows, and interventions that reduce contamination or transfusion-transmissible infection risk. Third, it targets improvements in how blood is delivered to patients, meaning the systems that move blood from collection sites to facilities and ultimately to bedside use, including inventory management, distribution networks, coordination across hospitals and blood centers, and methods to avoid delays during emergencies. The program is explicitly interested in approaches that are effective, sustainable, and scalable rather than solutions that only work under unusually resource-intensive conditions.

The applicant pool is broad, reflecting the program's interest in cross-sector partnerships and implementable solutions. Eligible applicants include various levels of government entities, public and private institutions of higher education, nonprofit organizations (including those with and without 501(c)(3) status), tribal governments and tribal organizations, public housing authorities/Indian housing authorities, for-profit organizations (other than small businesses), and small businesses, along with additional eligible entities as described in the full announcement. This wide eligibility supports collaborations among research institutions, blood services, ministries of health, hospitals, community organizations, and private-sector or technology partners that may contribute to operational improvements.

From an administrative standpoint, the opportunity sits within NIH's health research activity category and is associated with CFDA numbers 93.839 and 93.840. The announcement was created on March 11, 2019, with an original closing date of May 20, 2019. The listed award ceiling is $415,000, and the expected number of awards is three, indicating a relatively selective competition oriented toward a small set of rigorously designed projects with high potential for impact.

In summary, BLOODSAFE funds applied research in Sub-Saharan Africa that aims to make safe blood more available for transfusion by strengthening donor supply, improving safety and quality systems, and solving delivery and access barriers, particularly for high-risk populations such as children with severe anemia from malaria or sickle cell disease and women facing obstetric hemorrhage. The program is structured to support not just promising ideas, but approaches that can be implemented within existing constraints and sustained in routine practice.

  • The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "BLOODSAFE: Research to enhance availability of safe blood for patients with severe anemia and hemorrhagic conditions in low or lower-middle income countries (LLMICs) in Sub-Saharan Africa (UG3/UH3 Clinical Trial Optional)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.839, 93.840.
  • This funding opportunity was created on Mar 11, 2019.
  • Applicants must submit their applications by May 20, 2019. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Each selected applicant is eligible to receive up to $415,000.00 in funding.
  • The number of recipients for this funding is limited to 3 candidate(s).
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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